RefSeq (protein)



Location (UCSC) Chr 2: 176.11 – 176.12 Mb Chr 2: 74.69 – 74.7 Mb PubMed search [3] [4] Wikidata
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Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.[5]


This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.[5][citation needed]


The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.[6][7][8]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128710 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050368 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: HOXD10 homeobox D10". 
  6. ^ Lund AH (Feb 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655. 
  7. ^ Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature. 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713. 
  8. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (Aug 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. doi:10.4161/cbt.6.8.4486. PMID 17660710. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.