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NM_002144

NM_008266

RefSeq (protein)

NP_002135

NP_032292

Location (UCSC) Chr 17: 48.53 – 48.53 Mb Chr 11: 96.37 – 96.37 Mb PubMed search [3] [4] Wikidata
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Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.[5][6][7]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.[7]

Interactions

HOXB1 has been shown to interact with PBX1.[8][9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120094 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018973 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  6. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  7. ^ a b "Entrez Gene: HOXB1 homeobox B1". 
  8. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491Freely accessible. PMID 9482740. 
  9. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.