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NM_030661
NM_153631
NM_153632

NM_010452

RefSeq (protein)

NP_109377
NP_705895

NP_034582

Location (UCSC) Chr 7: 27.11 – 27.15 Mb Chr 6: 52.17 – 52.21 Mb PubMed search [3] [4] Wikidata
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Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[5][6][7]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[7]

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105997 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079560 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  6. ^ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  7. ^ a b "Entrez Gene: HOXA3 homeobox A3". 
  8. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (August 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. doi:10.4161/cbt.6.8.4486. PMID 17660710. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.