RefSeq (protein)



Location (UCSC) Chr 4: 173.33 – 173.34 Mb Chr 8: 57.51 – 57.52 Mb PubMed search [3] [4] Wikidata
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High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.[5][6]


This gene encodes a member of the non-histone chromosomal high-mobility group protein family.[7] The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164104 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054717 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Dec 1991). "Sequence of human HMG2 cDNA". Nucleic Acids Research. 19 (23): 6643. doi:10.1093/nar/19.23.6643. PMC 329240Freely accessible. PMID 1754403. 
  6. ^ a b "Entrez Gene: HMGB2 high-mobility group box 2". 
  7. ^ Murugesapillai D, McCauley MJ, Maher LJ, Williams MC (15 November 2016). "Single-molecule studies of high-mobility group B architectural DNA bending proteins". Biophysical Reviews. doi:10.1007/s12551-016-0236-4. 

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