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HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".[1] A 2007 study showed variations in HMGA2 to have a moderate association with adult height.[2][3]

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References

  1. ^ Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science. 315 (5818): 1576–1579. doi:10.1126/science.1137999. PMC 2556962Freely accessible. PMID 17322030. 
  2. ^ "Scientists discover height gene". BBC News. 2007-09-03. Retrieved 2007-09-03. 
  3. ^ Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–1250. doi:10.1038/ng2121. PMC 3086278Freely accessible. PMID 17767157. 

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