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NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

NP_766151

Location (UCSC) Chr 17: 55.27 – 55.33 Mb Chr 11: 90.34 – 90.39 Mb PubMed search [3] [4] Wikidata
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Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108924 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003949 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. doi:10.1126/science.1386162. PMID 1386162. 
  6. ^ a b "Entrez Gene: HLF hepatic leukemia factor". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.