2WFT, 2WFX, 2WG3, 2WG4, 3HO3, 3HO4, 3HO5

Identifiers Aliases HHIP, HIP, hedgehog interacting protein External IDs MGI: 1341847 HomoloGene: 32469 GeneCards: HHIP
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HHIP
Genomic location for HHIP
Band 4q31.21 Start 144,646,021 bp[1]
End 144,745,271 bp[1]
RNA expression pattern
PBB GE HHIP gnf1h05971 at fs.png

PBB GE HHIP gnf1h05972 at fs.png
More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 144.65 – 144.75 Mb Chr 8: 79.97 – 80.06 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.[5][6][7]

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164161 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064325 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet Cell Genet. 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703. 
  6. ^ Ingham PW, McMahon AP (Dec 2001). "Hedgehog signaling in animal development: paradigms and principles". Genes Dev. 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473. 
  7. ^ a b "Entrez Gene: HHIP hedgehog interacting protein". 

Further reading