Trifunctional purine biosynthetic protein adenosine-3 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''GART''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This protein is a trifunctional polypeptide. It has
Phosphoribosylamine—glycine ligase
''Phosphoribosylamine—glycine ligase'', also known as glycinamide ribonucleotide synthetase (GARS), () is an enzyme that catalyzes the chemical reaction
:ATP + 5-phospho-D-ribosylamine + glycine \rightleftharpoons ADP + phosphate +
which i ...
(EC 6.3.4.13),
Phosphoribosylglycinamide formyltransferase
Phosphoribosylglycinamide formyltransferase (, ''2-amino-N-ribosylacetamide 5'-phosphate transformylase'', ''GAR formyltransferase'', ''GAR transformylase'', ''glycinamide ribonucleotide transformylase'', ''GAR TFase'', ''5,10-methenyltetrahydrofol ...
(EC 2.1.2.2),
AIR synthetase (FGAM cyclase)
Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) is the fifth enzyme () in the ''de novo'' synthesis of purine nucleotides. It catalyzes the reaction to form 5-aminoimidazole ribotide (AIR) from formylglycinamidine-ribonucleotide F ...
(EC 6.3.3.1) activity which is required for de novo
purine
Purine is a heterocyclic compound, heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which includ ...
biosynthesis.
References
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{{Protein-stub