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The Info List - Geranyl Pyrophosphate





Geranyl pyrophosphate
Geranyl pyrophosphate
(GPP), also known as geranyl diphosphate (GDP), is an intermediate in the HMG-CoA reductase pathway
HMG-CoA reductase pathway
used by organisms in the biosynthesis of farnesyl pyrophosphate, geranylgeranyl pyrophosphate, cholesterol, terpenes and terpenoids.[1]

Isopentenyl pyrophosphate
Isopentenyl pyrophosphate
(IPP) and dimethylallyl pyrophosphate (DMAPP) are condensed by geranyl pyrophosphate synthase (dimethylallyltranstransferase) to produce geranyl pyrophosphate (GPP) and pyrophosphate. The carbon skeletons of DMAPP and IPP have been colored to indicate their location in GPP.

Related compounds[edit]

Geraniol Farnesyl pyrophosphate Geranylgeranyl pyrophosphate

See also[edit]

Dimethylallyltranstransferase

References[edit]

^ Kulkarni RS, Pandit SS, Chidley HG, Nagel R, Schmidt A, Gershenzon J, Pujari KH, Giri AP and Gupta VS, 2013, Characterization of three novel isoprenyl diphosphate synthases from the terpenoid rich mango fruit. Plant Physiology and Biochemistry, 71, 121–131.

v t e

Cholesterol
Cholesterol
and steroid metabolic intermediates

Mevalonate pathway

to HMG-CoA

Acetyl-CoA Acetoacetyl-CoA HMB HMB-CoA HMG-CoA

Ketone bodies

Acetone Acetoacetic acid β-Hydroxybutyric acid

to DMAPP

Mevalonic acid Phosphomevalonic acid 5-Diphosphomevalonic acid Isopentenyl pyrophosphate Dimethylallyl pyrophosphate

Geranyl-

Geranyl pyrophosphate Geranylgeranyl pyrophosphate

Carotenoid

Prephytoene diphosphate Phytoene

Non-mevalonate pathway

DOXP MEP CDP-ME CDP-MEP MEcPP HMB-PP IPP DMAPP

To Cholesterol

Farnesyl pyrophosphate Squalene 2,3-Oxidosqualene Lanosterol

Lanosterol Lathosterol 7-Dehydrocholesterol Cholesterol

Lanosterol Zymosterol 7-Dehydrodesmosterol Desmosterol Cholesterol

From Cholesterol (to steroids)

22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol

Steroid
Steroid
hormones

See here instead.

Nonhuman

Phytosterols

Stigmasterol Brassicasterol

Ergosterols

Ergosterol Ergocalciferol

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