Gem-associated protein 7 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''GEMIN7''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
The gem-associated proteins are those found in the
gems of Cajal bodies.
Function
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of
Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
Interactions
Gem-associated protein 7 has been shown to
interact
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with
SMN1
Survival of motor neuron 1 (''SMN1''), also known as component of gems 1 or ''GEMIN1'', is a gene that encodes the SMN protein in humans.
Gene
''SMN1'' is the telomeric copy of the gene encoding the SMN protein; the centromeric copy is term ...
and
Gem-associated protein 6
Gem-associated protein 6 is a protein that in humans is encoded by the ''GEMIN6'' gene. The gem-associated proteins are those found in the gems of Cajal bodies.
Function
GEMIN6 is part of a large macromolecular complex, the SMN localized to b ...
.
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Gem-associated protein 7
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