Gaston Ramon (30 September 1886 – 8 June 1963) was a French

veterinarian A veterinarian (vet), also known as a veterinary surgeon or veterinary physician, is a medical professional who practices veterinary medicine. They manage a wide range of health conditions and injuries in non-human animals. Along with this, vet ...

and

biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual cell, a multicellular organism, or a community of interacting populations. They usually specialize ...

best known for his role in the treatment of

diphtheria Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...

and

tetanus Tetanus, also known as lockjaw, is a bacterial infection caused by ''Clostridium tetani'', and is characterized by muscle spasms. In the most common type, the spasms begin in the jaw and then progress to the rest of the body. Each spasm usually ...

. He was born in

Bellechaume Bellechaume () is a commune in the Yonne department in Bourgogne-Franche-Comté in north-central France. See also *Communes of the Yonne department The following is a list of the 423 communes of the Yonne department of France. The communes ...

(

Yonne Yonne () is a department in the Bourgogne-Franche-Comté region in France. It is named after the river Yonne, which flows through it, in the country's north-central part. One of Bourgogne-Franche-Comté's eight constituent departments, it is l ...

France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...

) and attended l'École vétérinaire d'Alfort from 1906 to 1910. In 1917 he married Marthe Momont, grandniece of

Emile Roux Emil or Emile may refer to: Literature *''Emile, or On Education'' (1762), a treatise on education by Jean-Jacques Rousseau * ''Émile'' (novel) (1827), an autobiographical novel based on Émile de Girardin's early life *''Emil and the Detective ...

. During the 1920s, Ramon, along with P. Descombey, made major contributions to the development of effective

vaccines A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified.

for both

and

. In particular, he developed a method for inactivating the diphtheria

toxin A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849 ...

and the tetanus toxin using

formaldehyde Formaldehyde ( , ) ( systematic name methanal) is a naturally occurring organic compound with the formula and structure . The pure compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde (refer to section ...

which, in its essentials, is still used in vaccines manufactured today. He also developed a method for determining the potency of the vaccines, an essential element required for the reproducible production of these pharmaceuticals. He received 155 Nobel Prize Nominations but never received the prize. A collection of his papers is held at the

National Library of Medicine The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library. Located in Bethesda, Maryland, the NLM is an institute within the National Institutes of Health. Its ...

Bethesda, Maryland Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which ...

References

Bibliography

Ebisawa, I. 1987. The encounter of Gaston Ramon (1886-1963) with formalin: A biographical study of a great scientist. Kitasato Archives of Experimental Medicine 60 (3): 55-70. {{DEFAULTSORT:Ramon, Gaston 1886 births 1963 deaths People from Yonne French biologists Members of the French Academy of Sciences 20th-century biologists