Garcinia gummi-gutta is a tropical species of Garcinia native to Indonesia. Common names include Garcinia cambogia (a former scientific name), as well as brindleberry, Malabar tamarind, and kudam puli (pot tamarind). This fruit looks like a small pumpkin and is green to pale yellow in color.
Although it has received considerable media attention purporting its effects on weight loss, there is liver toxicity associated with commercial preparations of the fruit extract with clinical evidence indicating it has no significant effect on weight loss.
Garcinia gummi-gutta is one of several closely related Garcinia species from the plant family Clusiaceae. With thin skin and deep vertical lobes, the fruit of G. gummi-gutta and related species range from about the size of an orange to that of a grapefruit; G. gummi-gutta looks more like a small yellowish, greenish, or sometimes reddish pumpkin. The color can vary considerably. When the rinds are dried and cured in preparation for storage and extraction, they are dark brown or black in color.
Along the west coast of South India, G. gummi-gutta is popularly termed "Malabar tamarind", and shares culinary uses with the tamarind (Tamarindus indica). The latter is a small and the former a quite large evergreen tree. G. gummi-gutta is also called goraka or, in some areas, simply kattcha puli (souring fruit). It is called uppage in Kannada language and fruits are collected and dried for selling to dealers in Sirsi, Karnataka.
Garcinia gummi-gutta is used in cooking, including in the preparation of curries. The fruit rind and extracts of Garcinia species are called for in many traditional recipes, and various species of Garcinia are used similarly in food preparation in Assam (India), Thailand, Malaysia, Burma, and other Southeast Asian countries. In the Indian Ayurvedic medicine, "sour" flavors are said to activate digestion. The extract and rind of G. gummi-gutta is a curry condiment in India. It is an essential souring ingredient in the southern Thai variant of kaeng som, a sour curry.
Garcinia gummi-gutta is used commercially in fish curing, especially in Sri Lanka and South India. The trees can be found in forested areas and also are protected in plantations otherwise given over to pepper, spice, and coffee production.
In late 2012, a United States celebrity doctor, Dr. Oz, promoted Garcinia cambogia extract as "an exciting breakthrough in natural weight loss". Dr. Oz's endorsements of dietary supplements having no or little scientific evicence of efficacy have often led to a substantial increase in consumer purchases of the promoted products.
While it has received considerable media attention purporting impact on weight loss, the evidence for Garcinia cambogia supports no clear effect, while gastrointestinal adverse events were two-fold more common over the placebo in a 2011 meta-analysis indicating the extract may be unsafe for human consumption. Adverse events associated with use of such supplements ("side effects") — especially, hepatotoxicity, as well as gastrointestinal issues — led to one preparation being withdrawn from the market.
Orally, 500 mg of hydroxycitric acid four times daily can cause nausea, gastrointestinal discomfort, and headaches.
One case report of a patient who developed "Serotonin Syndrome" after taking Garcinia cambogia at the same time as Escitalopram was published in the December 2014 Journal of Medical Toxicology. Caution should be exercised in patients treated with the following class of medications who are looking to manage their weight issue using Garcinia cambogia:
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