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''Garcinia gummi-gutta'' is a
tropical The tropics are the regions of Earth surrounding the Equator. They are defined in latitude by the Tropic of Cancer in the Northern Hemisphere at N and the Tropic of Capricorn in the Southern Hemisphere at S. The tropics are also referred to ...
species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...
of ''
Garcinia ''Garcinia'' is a genus of flowering plants in the family Clusiaceae native to Asia, America, Australia, tropical and southern Africa, and Polynesia. The number of species is disputed; Plants of the World Online (POWO) recognise up to 400. Common ...
'' native to
South Asia South Asia is the southern subregion of Asia, which is defined in both geographical Geography (from Greek: , ''geographia''. Combination of Greek words ‘Geo’ (The Earth) and ‘Graphien’ (to describe), literally "earth descr ...
and
Southeast Asia Southeast Asia, also spelled South East Asia and South-East Asia, and also known as Southeastern Asia, South-eastern Asia or SEA, is the geographical south-eastern region of Asia, consisting of the regions that are situated south of mainlan ...
. Common names include ''Garcinia cambogia'' (a former scientific name), as well as brindle berry, and Malabar tamarind. The
fruit In botany, a fruit is the seed-bearing structure in flowering plants that is formed from the ovary after flowering. Fruits are the means by which flowering plants (also known as angiosperms) disseminate their seeds. Edible fruits in particu ...
looks like a small pumpkin and is green to pale yellow in color. Although it has received considerable media attention purporting its effects on
weight loss Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat ( adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other co ...
, there are reports of liver toxicity associated with the ''Hydroxycut'' commercial preparation containing the fruit extract, with clinical evidence indicating it has no significant effect on weight loss.


Cultivation

''Garcinia gummi-gutta'' is grown for its fruit in
Southeast Asia Southeast Asia, also spelled South East Asia and South-East Asia, and also known as Southeastern Asia, South-eastern Asia or SEA, is the geographical south-eastern region of Asia, consisting of the regions that are situated south of mainlan ...
and
South Asia South Asia is the southern subregion of Asia, which is defined in both geographical Geography (from Greek: , ''geographia''. Combination of Greek words ‘Geo’ (The Earth) and ‘Graphien’ (to describe), literally "earth descr ...
. ''Garcinia gummi-gutta'' is one of several closely related ''Garcinia'' species from the plant family
Clusiaceae The Clusiaceae or Guttiferae Juss. (1789) (''nom. alt. et cons.'' = alternative and valid name) are a family (biology), family of plants including 13 genera and ca 750 species. Several former members of Clusiacae are now placed in Calophyllaceae ...
. With thin skin and deep vertical lobes, the fruit of ''G. gummi-gutta'' and related species range from about the size of an orange to that of a grapefruit; ''G. gummi-gutta'' looks more like a small yellowish, greenish, or sometimes reddish pumpkin. The color can vary considerably. When the rinds are dried and cured in preparation for storage and extraction, they are dark brown or black in color.


Phytochemicals

Although few high-quality studies have been done to define the composition of the fruit, its phytochemical content includes
hydroxycitric acid Hydroxycitric acid (HCA) is a derivative of citric acid that is found in a variety of tropical plants including '' Garcinia cambogia'' and ''Hibiscus sabdariffa''. There are four isomers, (+)- and (-)-hydroxycitric acid, and (+)- and (-)-allo-hyd ...
which is extractable and developed as a dietary supplement. Other compounds identified in the fruit include the
polyphenol Polyphenols () are a large family of naturally occurring organic compounds characterized by multiples of phenol units. They are abundant in plants and structurally diverse. Polyphenols include flavonoids, tannic acid, and ellagitannin, some o ...
s,
luteolin Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance. Luteolin is the principal yellow dye compound that is obtained from the plant '' Reseda luteola'', which has been used as a source of the dye since at least the f ...
, and
kaempferol Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. Kaempferol is a yellow crystalline solid with a meltin ...
.


Common names

In the
Malabar Coast The Malabar Coast is the southwestern coast of the Indian subcontinent. Geographically, it comprises the wettest regions of southern India, as the Western Ghats intercept the moisture-laden monsoon rains, especially on their westward-facing m ...
, it is known as ''kudam puli'' and in Tamil speaking areas of Sri Lanka and India, it is called ''goraka''.


Weight loss claims

In late 2012, a United States
celebrity doctor Celebrity doctors include physicians, medical professionals, people with the title doctor, and some with the nickname "doctor" who have extensive media exposure. Some may have a secondary role as an entertainer. Examples of celebrity doctors inclu ...
, Dr. Oz, promoted ''Garcinia cambogia'' extract as "an exciting breakthrough in natural weight loss". Dr. Oz's endorsements of dietary supplements having no or little scientific evidence of efficacy have often led to a substantial increase in consumer purchases of the promoted products. While it has received considerable media attention purporting impact on
weight loss Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat ( adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other co ...
, the evidence for ''Garcinia cambogia'' supports no clear effect, while gastrointestinal adverse events were two-fold more common over the
placebo A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. In general, placebos can af ...
in a 2011
meta-analysis A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting me ...
, indicating the extract may be unsafe for human consumption. Adverse events associated with use of such supplements ("
side effects In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...
") — especially, liver toxicity, as well as
gastrointestinal The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and ...
issues — led to one preparation being withdrawn from the market.


Adverse effects

In addition to possible liver damage, hydroxycitric acid can cause
dry mouth Xerostomia, also known as dry mouth, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause. This symptom is very common and is often seen as a side eff ...
,
nausea Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the ...
,
gastrointestinal The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and ...
discomfort, and headaches.


Drug interactions

There is potential for ''Garcinia cambogia'' to interfere with
prescription medication A prescription drug (also prescription medication or prescription medicine) is a pharmaceutical drug that legally requires a medical prescription to be dispensed. In contrast, over-the-counter drugs can be obtained without a prescription. The r ...
s, including those used to treat people with
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...
,
asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, co ...
, and
clotting Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism o ...
disorders.


Culinary

''Garcinia gummi-gutta'' is used in cooking, including in the preparation of curries to add a sour flavor. The fruit rind and extracts of ''Garcinia'' species are used in many traditional recipes used in food preparation in Southeast Asian countries."The acid rinds of the ripe fruit are eaten,." In the Indian
Ayurvedic medicine Ayurveda () is an alternative medicine system with historical roots in the Indian subcontinent. The theory and practice of Ayurveda is pseudoscientific. Ayurveda is heavily practiced in India and Nepal, where around 80% of the population rep ...
, "sour" flavors are said to activate digestion. The extract and rind of ''G. gummi-gutta'' is a
curry A curry is a dish with a sauce seasoned with spices, mainly associated with South Asian cuisine. In southern India, leaves from the curry tree may be included. There are many varieties of curry. The choice of spices for each dish in trad ...
condiment in India. It is an essential souring ingredient in the southern Thai variant of ''
kaeng som Thai curry ( th, แกง, translit=kaeng, ) is a dish in Thai cuisine made from curry paste, coconut milk or water, meat, seafood, vegetables or fruit, and herbs. Curries in Thailand mainly differ from the curries in India in their use of in ...
'', a sour curry.


Gallery

File:Bark of Garcinia cambogia.jpg, Bark File:Garcinia gummi-gutta Kudampuli C.S. of fruit.jpg, Cross section File:കുടം‌പുളി.jpg, Drying in smoke


See also

*''
Garcinia binucao ''Garcinia binucao'' is a species of flowering plant in the Clusiaceae family. It is commonly known as binukaw or batuan, is a species of ''Garcinia'' endemic to the Philippines. It is not cultivated, though its edible fruits are harvested from ...
'' *''
Garcinia dulcis ''Garcinia dulcis'' is a tropical fruit tree native to the Philippines, Java, Lesser Sunda Islands, eastern Indonesia (Sulawesi, Kalimantan, and the Maluku Islands), and Papua New Guinea. It was domesticated early and spread inland into mainland ...
'' *''
Garcinia morella ''Garcinia morella'' is a species of tree in the family Clusiaceae found in India, and Sri Lanka. Common names * Assamese: Kũzi Thekera (কুঁঁজী ঠেকেৰা) *English: ''gamboge'' (Sri Lanka), ''gamboge'' (India) *Tamil: ''ira ...
''


References

{{Taxonbar, from=Q18187249 gummi-gutta Medicinal plants of Africa Medicinal plants of Asia Indian spices Spices Plants described in 1814