Gadofosveset (trade names Vasovist, Ablavar) is a

gadolinium-based MRI contrast agent MRI contrast agents are contrast agents used to improve the visibility of internal body structures in magnetic resonance imaging (MRI). The most commonly used compounds for contrast enhancement are gadolinium-based. Such MRI contrast agents shorten ...

. It was used as the trisodium salt monohydrate form. It acts as a

blood pool agent Blood pool agents (BPAs) are a class of magnetic resonance angiography contrast agents. Blood pool agents (also known as intravascular contrast agents) are differentiated from other contrast agents due to their high molecular weight and higher Relax ...

by binding to

human serum albumin Human serum albumin is the serum albumin found in human blood. It is the most abundant protein in human blood plasma; it constitutes about half of serum protein. It is produced in the liver. It is soluble in water, and it is monomeric. Albumin ...

. The manufacturer (Lantheus Medical) discontinued production in 2017 due to poor sales. Gadofosveset facilitates high-resolution

magnetic resonance angiography Magnetic resonance angiography (MRA) is a group of techniques based on magnetic resonance imaging (MRI) to image blood vessels. Magnetic resonance angiography is used to generate images of arteries (and less commonly veins) in order to evaluate ...

. Ferumoxytol (trade names Feraheme, Rienso), an intravenous iron-replacement therapy, has been shown to potentially be superior to gadofosveset as a blood pool agent for MR venography in pediatric patients.

References

MRI contrast agents Organogadolinium compounds {{pharma-stub