GTx, Inc. is a

pharmaceutical company The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate sympt ...

that is working on drugs in the

selective estrogen receptor modulator Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonist/antagonists (ERAAs), are a class of drugs that act on the estrogen receptor (ER). A characteristic that distinguishes these substances from pure ER agonists ...

(SERM) and selective androgen receptor modulator (SARM) classes. Its drugs in development include enobosarm (ostarine) and

GTx-758 GTx-758 (tentative brand name Capesaris) is a synthetic nonsteroidal estrogen which was under development by GTx, Inc. for the treatment of advanced prostate cancer. As of 2016, it had completed two phase II clinical trials. Pharmacology Pha ...

. The company was founded in Memphis in 1997 by Mitch Steiner and Marc S. Hanover. The company was originally called Genotherapeutics, changed its name to GTx, Inc. in 2001, and reincorporated in Delaware in 2003. The company licensed toremifene from Orion Corporation, and licensed andarine, enobosarm and prostarine from the University of Tennessee Research Foundation; the SARM compounds from Tennessee had been invented by Karen Veverka and Michael Whitt and each later joined the company. The company held its IPO in February 2004. In 2006 GTx signed a partnership with Ipsen to develop toremifene, a selective estrogen receptor modulatorm to prevent prostate cancer and to prevent bone loss in men with prostate cancer; the FDA rejected the application to market the drug for this use in 2009, and Ipsen terminated the arrangement in 2011. In 2012 GTx sold its rights to toremifene to ProStrakan, a subsidiary of

Kyowa Hakko Kirin is a Japanese pharmaceutical and biotechnology company under the Kirin Holdings, and is among the 40 largest in the world by revenue. The company is headquartered in Chiyoda-ku, Tokyo and is a member of the Nikkei 225 stock index. History On ...

, for around $19 million, and terminated its agreement with Orion. By 2007 enobosarm was in a Phase II trial, and that year Gtx signed an exclusive license agreement for its SARM program with Merck; Merck bought $30M in GtX stock, paid an upfront fee of $40M, and agreed to fund $15M in research over the next three years. The agreement also included royalties on any product brought to market and around $400M in biodollars. The companies ended the deal in 2010. In August 2013 GTx announced that enobosarm had failed in two Phase III clinical trials to treat wasting in people with lung cancer. In October 2013 the company laid off around 60% of its 88-person workforce, and Steiner resigned 6 months later. The company had invested around $35 million in the development of the drug. The company said at that time that is planned to pursue approval of enobosarm in Europe; the company was also still developing GTx-758 for castration-resistant prostate cancer. In 2016 GTx began Phase II trials, to see if enosobarm might be effective to treat stress urinary incontinence in women. In June 2019, GTx combined with Oncternal Therapeutics in a reverse merger. The combined company will operate under the name Oncternal Therapeutics, Inc.

References

Pharmaceutical companies of the United States Pharmaceutical companies established in 1997 Companies listed on the Nasdaq Companies based in Memphis, Tennessee Health care companies based in Tennessee {{Med-company-stub