GPR113 is a

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

that encodes the Probable G-protein coupled receptor 113

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

Gene

The ''Homo sapiens'' GPR113 gene is located on chromosome 2 (2p23.3). This gene spans the length of a 38.65kb region from base 26531041 to 26569685 on the negative strand. The GPR113 gene has two neighbors on either side on the negative strand
OTOF otoferlin
preceding an
HADHA hydroxyacyl-CoA
following. Directly opposite the GPR113 on the positive strand is th
EPT1
gene. The GPR113 gene is also known by the aliases PGR23 and HGPCR37.

Homology & Evolution

The GPR113 has 5 human paralog
GPR110GPR115GPR128GPR111
an
GPR116
GPR113 is well conserved in mammals from primates to semi-aquatic species, as well as some amphibians. These include the Common Chimpanzee, the African Bush Elephant, the Platypus, and the Western Clawed Frog. Homologous domains that are well conserved throughout orthologs center in th
7 transmembrane receptor (Secretin family)
region highlighted in purple in the figure.

Protein

The protein product of GPR113 gene is a G-protein coupled receptor. The protein has three transcript variants in humans. Of these three, GPR113 Variant 1 has the longest amino acid sequence, and has the highest identity to orthologs. This leads to the conclusion that GPR113 Variant 1 is the homo sapiens descendant of the ancestral GPR113 gene. GPR113 Var 1 contains 1079 Amino Acids, and is integral to the plasma membrane. The 7-pass receptor contains 4 domains highlighted in the figure at right: Signal Peptide (Red)
Hormone Receptor Domain
(Blue)
Latrophilin/CL-1-like GPS domain
(Orange), and the 7-transmembrane receptor (Purple). Between the Hormone Receptor Domain and the GPS is a Domain of unknown function that is not highlighted.

Function

GPR113 is a

G protein-coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

that is involved in a neuropeptide signaling pathway.

Expression & Disease

GPR113 has been found to be expressed differentially under diseased conditions. Under the condition of

Type 2 diabetes Type 2 diabetes, formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urinatio ...

, the percentile rank relative to other transcripts decreases relative to normal cell function. The deletion of

TP63 Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63 is a protein that in humans is encoded by the ''TP63'' (also known as the '' p63'') gene. The ''TP63'' gene was discovered 20 years after the discove ...

, which mediates a wide variety of important body processes, also produces decreased GPR113 expression. In mice brains, the cerebellum and the olfactory bulb both show transcription of the GPR113 gene. Additionally, a study from the National Institute of Deafness and Other Communication Disorders has identified GPR113 expression to be highly restricted to a subset of taste receptor cells. This paper's conclusions, coupled with olfactory bulb expression levels, could provide an avenue for future research, potentially illuminating more about GPR113's function.

Interacting Proteins

GPR113 has been shown to associate with the orphan G protein-coupled receptor

GPR123 Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the ''GPR123'' gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a v ...

Transcription Factors

Clinical significance

The clinical significance of this protein has not been established. However, the expression profiles provide exciting directions for future research of the GPR113 gene, especially in fields studying taste and smell.