Guanine nucleotide-binding protein subunit beta-5 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''GNB5''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

. Alternatively spliced transcript variants encoding different isoforms exist.

Function

Heterotrimeric guanine nucleotide-binding proteins (

G protein G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their act ...

s), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. GNB5 has been shown to differentially control

RGS protein Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that function to activate the GTPase activity of heterotrimeric G-protein G alpha subunit, α-subunits. RGS proteins are multi-func ...

stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.

Interactions

GNB5 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with: *

GNG7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the ''GNG7'' gene. Interactions GNG7 has been shown to interact with GNB5 Guanine nucleotide-binding protein subunit beta-5 is a prote ...

, *

GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the ''GNG13'' gene. Interactions GNG13 has been shown to interact with GNB5 Guanine nucleotide-binding protein subunit beta-5 is a pr ...

, *

RGS7 Regulator of G-protein signaling 7 is a protein that in humans is encoded by the ''RGS7'' gene. RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accele ...

and *

RGS9 Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the acti ...

Function

Interactions

References

Further reading