GBR-13098 is a psychostimulant and selective
dopamine uptake inhibitor.
Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by
malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of
mitochondrial dysfunction
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. Mitochondria are the organelles that generate energy for the cell and are found in every cell of the human body except red blood cells. They convert the energy of ...
on DA homeostasis.
See also
*
Vanoxerine
*
GBR-12783
*
GBR-12935
*
GBR-13069
*
DBL-583
References
Stimulants
Dopamine reuptake inhibitors
1-(2-(Bis(4-fluorophenyl)methoxy)ethyl)piperazines
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