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Fred (Friedrich) Neufeld (17 February 1869 in Danzig
Danzig
– 18 April 1945 in Berlin) was a physician and bacteriologist who discovered the pneumococcal types. This discovery led Fred Griffith
Fred Griffith
to show that one pneumococcal type could be transformed into another (Griffith's experiment). Subsequently, Oswald Avery
Oswald Avery
demonstrated that the transforming substance was DNA. All modern molecular biology has evolved from this work.

Fred Neufeld

Born 17 February 1869 Danzig

Died 18 April 1945, age 76 Berlin, Germany

Nationality German

Occupation physician, bacteriologist

Known for discovery of pneumococcal types

Contents

1 Early years 2 Neufeld's discoveries 3 Later life 4 References

Early years[edit] Neufeld was the son of a physician. He was musically talented and a gifted pianist. In 1894, Neufeld became assistant to Robert Koch. He worked with Koch on studies of tuberculosis and went to Rhodesia with Koch in 1903 to study rinderpest.[1] Neufeld's discoveries[edit] In 1900 Neufeld discovered bile solubility of pneumococci.[2] Addition of a small amount of ox bile to a pneumococcal culture results in complete destruction of the culture after a short incubation. This unique property became widely used to diagnose pneumococcal infections. Then, using immunological techniques, Neufeld discovered that there were three pneumococcal types. In the presence of type I antiserum type I pneumococci would swell, likewise types II and III in the presence of their specific antisera. Neufeld called this the Quellung reaction, after the German word for swelling.[3][4] The Quellung reaction allowed for easy laboratory identification of pneumococcal types.[5] Using Neufeld’s discoveries, Fred Griffith showed that pneumococci could transfer genetic information and transform one type into another.[6] Oswald Avery
Oswald Avery
then found that the transforming substance was DNA. All of modern molecular biology has evolved from this work. Later life[edit]

Photomicrograph of pneumococci revealing capsular swelling using the Neufeld-Quellung test.

From 1917 to 1933, Neufeld was director of the Robert Koch
Robert Koch
Institute in Berlin. He never married and lived with his mother until her death. When the Nazis came to power they immediately demoted Neufeld, although he was Protestant (Mennonite), not Jewish. Neufeld remained on the Institute staff as an "honorary member" (Ehrenmitglied) and continued to publish. In 1939 he was nominated for the Goethe-Medaille für Kunst und Wissenschaft for his scientific achievements, but did not receive the honour until Feb. 17, 1944, his 75th birthday. Neufeld died in war torn Berlin of “Entkräftung” (wasting).[7] References[edit]

^ Lehrer, Steven (2006). Explorers of the Body (2nd ed.). United States: iUniverse,Inc. ISBN 0-595-40731-5.  ^ Neufeld F. Über eine spezifische bakteriolytische Wirkung der Galle. Zeitschrift fur Hygiene Infektionskrankheiten. 1900;34:454-64. ^ Neufeld F. Über die Agglutination der Pneumokokken und über die Theorieen der Agglutination. Zeitschrift fur Hygiene Infektionskrankheiten. 1902;40:54-72. ^ Neufeld F, Händel L. Weitere Untersuchungen über Pneumokokken Heilsera. III Mitteilung. Über Vorkommen und Bedeutung atypischer Varietäten des Pneumokokkus. Arbeit aus dem Kaiserlichen Gesundheitsamte. 1910;34:293-304. ^ Austrian, Robert. A Brief History of Pneumococcal Vaccines. Review Article. Drugs & Aging. 15 Supplement 1:1-10, 1999 ^ Tuomanen, Elaine (2004). The pneumococcus. United States: ASM Press. ISBN 1-55581-297-X.  ^ Kleine, F.K. Fred Neufeld. Obituary (in German). Medical Microbiology and Immunology. Volume 127, Numbers 3-4 / June, 1947

Authority control

WorldCat Identities VIAF: 72174237 ISNI: 0000 0000 1058 3618 GND: 117551112

Double helix

William Astbury Oswald Avery Lawrence Bragg Francis Crick Erwin Chargaff Michael Creeth Jerry Donohue Rosalind Franklin Raymond Gosling Frederick Griffith John Masson Gulland Denis Jordan Phoebus Levene Friedrich Miescher Fred Neufeld Sir John Randall Alex Stokes James Watson Maurice Wilkins Herbert Wilson Photo 51

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