Frank Portelli may refer to:
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Frank Portelli (artist)
Frank Portelli (1922-2004) was a mural artist and fine art painter from Malta whose work was exhibited at the Venice Biennale in 1958. Within a few months after his death, one of his murals was also acquired by Heritage Malta for the country's nati ...
(1922–2004), Maltese artist and mural painter
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Frank Portelli (politician) (born 1944), member of the Maltese Parliament
{{human name disambiguation, Portelli, Frank