Francesco Piccolomini may refer to:
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Pope Pius III
Pope Pius III ( it, Pio III; 9 May 1439 – 18 October 1503), born Francesco Todeschini, was head of the Catholic Church and ruler of the Papal States from 22 September 1503 to his death. At just twenty-six days, he had one of the shortes ...
(1439–1503), born Francesco Todeschini Piccolomini
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Francesco Piccolomini (1582–1651), Italian Jesuit
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Francesco Piccolomini (died 1622), bishop of Grosseto
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Francesco Piccolomini (1523–1607), professor of natural philosophy
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