Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (symbol FTCD in humans) is an enzyme that catalyzes the conversion of
formiminoglutamate and
tetrahydrofolate
Tetrahydrofolic acid (THFA), or tetrahydrofolate, is a folic acid derivative.
Metabolism
Human synthesis
Tetrahydrofolic acid is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by methotrexate.
It is co ...
into
formiminotetrahydrofolate and
glutamate.
Role in pathology
Mutations of the FTCD gene cause
glutamate formiminotransferase deficiency.
See also
*
Glutamate-1-semialdehyde
References
External links
*
{{lyase-stub