Fluspirilene (Redeptin, Imap, R6218) is a

diphenylbutylpiperidine Diphenylbutylpiperidines are a class of typical antipsychotic drugs which were all synthesized, developed, and marketed by Janssen Pharmaceutica. They include: * Clopimozide (R-29,764) * Fluspirilene (Redeptin) * Penfluridol (Semap, Micefal, Lon ...

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics ma ...

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...

, used for the treatment of

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...

. It is administered

intramuscularly Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle. In medicine, it is one of several methods for parenteral administration of medications. Intramuscular injection may be preferred because muscles have ...

. It was discovered at

Janssen Pharmaceutica Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based American c ...

in 1963.C. Janssen, NV Res. Lab., (1963) A 2007

systematic review A systematic review is a Literature review, scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from publ ...

investigated the efficacy of fluspirilene decanoate for people with schizophrenia:

Synthesis

*Sidechain precursor 312-04-7(1) also used for:

penfluridol Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and flus ...

clopimozide Clopimozide (R-29,764) is a typical antipsychotic drug of the diphenylbutylpiperidine class. It is very potent and has an extremely long duration of action, lasting at least one week with a single dose. It was developed by Janssen Pharmaceutica ...

, amperozide,

pimozide Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis i ...

lidoflazine Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964. Physical properties Solubility at room temperature Extracted from ...

. *Piperidine 021-25-6also used for Spiroxantrine,

Spiperone Spiperone (Spiroperidol; brand name: Spiropitan ( JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spiper ...

, Ro65-6570, RP-23618, Spirilene, Spiramide
R 5260
109-69-9 etc. Fluspirilene synthesis

1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) 312-04-7(1) & 1-Phenyl-1,3,8-Triazaspiro .5ecan-4-One 021-25-6(2) give ' (3).

References

Belgian inventions 1-(4,4-Bis(4-fluorophenyl)butyl)piperidines Janssen Pharmaceutica Typical antipsychotics Spiro compounds Anilines {{nervous-system-drug-stub

Synthesis

See also

References