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Phlegm (; , ''phlégma'', "inflammation", "
humour Humour (English in the Commonwealth of Nations, Commonwealth English) or humor (American English) is the tendency of experiences to provoke laughter and provide amusement. The term derives from the humorism, humoral medicine of the ancient Gre ...
caused by heat") is
mucus Mucus ( ) is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells. It is ...
produced by the
respiratory system The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies grea ...
, excluding that produced by the
nasal Nasal is an adjective referring to the nose, part of human or animal anatomy. It may also be shorthand for the following uses in combination: * With reference to the human nose: ** Nasal administration, a method of pharmaceutical drug delivery ** ...
passages. It often refers to respiratory mucus expelled by coughing, otherwise known as
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked eye examination, microbiological investigation of respiratory infections and cytological investigations ...
. Phlegm, and mucus as a whole, is in essence a water-based gel consisting of glycoproteins, immunoglobulins,
lipids Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include ...
and other substances. Its composition varies depending on
climate Climate is the long-term weather pattern in an area, typically averaged over 30 years. More rigorously, it is the mean and variability of meteorological variables over a time spanning from months to millions of years. Some of the meteorologic ...
,
genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...
, and state of the immune system. Its color can vary from transparent to pale or dark yellow and green, from light to dark brown, and even to dark grey depending on the constituents. The body naturally produces about 1 quart (about 1 litre) of phlegm every day to capture and clear substances in the air and bacteria from the nose and throat.


Distinction between mucus and phlegm

Contrary to popular misconception and misuse, mucus and phlegm are not always the same.


Mucus

Mucus is a normal protective layering around the airway, eye,
nasal turbinate In anatomy, a nasal concha (), plural conchae (), also called a nasal turbinate or turbinal, is a long, narrow, curled shelf of bone that protrudes into the breathing passage of the nose in humans and various animals. The conchae are shaped like ...
, and
urogenital tract The genitourinary system, or urogenital system, are the organs of the reproductive system and the urinary system. These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathwa ...
. Mucus is an adhesive viscoelastic gel produced in the airway by submucosal glands and
goblet cells Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 5AC. The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secre ...
and is principally water. It also contains high-molecular weight mucous glycoproteins that form linear polymers.


Phlegm

Phlegm is more related to disease than is mucus and can be troublesome for the individual to excrete from the body. Phlegm is a thick secretion in the airway during disease and inflammation. Phlegm usually contains mucus with virus, bacteria, other debris, and sloughed-off inflammatory cells. Once phlegm has been expectorated by a cough, it becomes
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked eye examination, microbiological investigation of respiratory infections and cytological investigations ...
.


Excessive phlegm creation

There are multiple factors that can contribute to an excess of phlegm in the throat or
larynx The larynx (), commonly called the voice box, is an organ in the top of the neck involved in breathing, producing sound and protecting the trachea against food aspiration. The opening of larynx into pharynx known as the laryngeal inlet is about ...
. *Vocal abuse: Vocal abuse is the misuse or overuse of the voice in an unhealthy fashion such as clearing the throat, yelling, screaming, talking loudly, or singing incorrectly. ** Clearing the throat: Clearing the throat removes or loosens phlegm but the vocal cords hit together causing inflammation and therefore more phlegm. ** Yelling/screaming: Yelling and screaming both cause the vocal cords to hit against each other causing inflammation and phlegm. **
Nodules Nodule may refer to: *Nodule (geology), a small rock or mineral cluster *Manganese nodule, a metallic concretion found on the seafloor *Nodule (medicine), a small aggregation of cells *Root nodule Root nodules are found on the roots of plants, p ...
: Excessive yelling, screaming, and incorrect singing as well as other vocal abusive habits can cause
vocal fold nodule Vocal cord nodules are bilaterally symmetrical benign white masses that form at the midpoint of the vocal folds. Although diagnosis involves a physical examination of the head and neck, as well as perceptual voice measures, visualization of the v ...
s. *
Smoking Smoking is a practice in which a substance is burned and the resulting smoke is typically breathed in to be tasted and absorbed into the bloodstream. Most commonly, the substance used is the dried leaves of the tobacco plant, which have bee ...
: Smoke is hot, dry, polluted air which dries out the vocal cords. With each breath in of smoke, the larynx is polluted with toxins that inhibit it from rehydrating for about 3 hours. The vocal cords need a fair amount of lubrication and swell from inflammation when they do not have enough of it. When the vocal folds swell and are inflamed, phlegm is often created to attempt to ease the dryness. **Experiment on smoking correlations: In 2002, an experiment was done and published by the
American College of Chest Physicians The American College of Chest Physicians (CHEST) is a medical association in the United States consisting of physicians and non-physician specialists in the field of chest medicine, which includes pulmonology, critical care medicine, and sleep med ...
to find if there was a correlation of smokers with coughing and phlegm. In the study, 117 participants were studied, a mix of current smokers, ex-smokers, non-smokers, and a positive control of participants with a disease, COPD ( Chronic Obstructive Pulmonary Disease). At the end of the experiment, experimenters found that there was a high correlation between phlegm and cough with smoking of 0.49 (p < 0.001.) * Illness: During illness like the flu, cold, and pneumonia, phlegm becomes more excessive as an attempt to get rid of the bacteria or viral particles within the body. A major illness associated with excess phlegm is
acute bronchitis Acute bronchitis, also known as a chest cold, is short-term bronchitis – inflammation of the bronchi (large and medium-sized airways) of the lungs. The most common symptom is a cough. Other symptoms include coughing up mucus, wheezing, shortne ...
. A major symptom of acute bronchitis is an excess amount of phlegm and is usually caused by a viral infection, and only bacterial infections, which are rare, are to be treated with an antibiotic. *
Hay fever Allergic rhinitis, of which the seasonal type is called hay fever, is a type of inflammation in the nose that occurs when the immune system overreacts to allergens in the air. Signs and symptoms include a runny or stuffy nose, sneezing, red, i ...
, asthma: In hay fever and asthma, inner lining in
bronchioles The bronchioles or bronchioli (pronounced ''bron-kee-oh-lee'') are the smaller branches of the bronchial airways in the lower respiratory tract. They include the terminal bronchioles, and finally the respiratory bronchioles that mark the start o ...
become inflamed and create an excess amount of phlegm that can clog up air pathways. * Air pollution: In studies of children, air pollutants have been found to increase phlegm by drying out and irritating parts of the throat.


Removing phlegm

Excessive phlegm creation can be troublesome. There are basically two ways to get rid of excess phlegm: swallowing or spitting. Phlegm naturally drains down into the back of the throat and can be swallowed without imposing health risks. Once in the stomach, the acids and
digestive system The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller compone ...
will remove the phlegm and get rid of the germs in it. In some cultures, swallowing phlegm is considered a social taboo, being described as disgusting or unhygienic. One Igbo
adage An adage (; Latin: adagium) is a memorable and usually philosophical aphorism that communicates an important truth derived from experience, custom, or both, and that many people consider true and credible because of its longeval tradition, i.e. ...
, for example, uses the swallowing of phlegm as a metaphor for
wrongdoing A wrong (from Old English – 'crooked') is an act that is illegal or immoral. Legal wrongs are usually quite clearly defined in the law of a state and/or jurisdiction. They can be divided into civil wrongs and crimes (or ''criminal offenses'') ...
. Also, due to the social image of spitting (the alternative of swallowing) in some communities, females were shown to be more likely to swallow phlegm and less likely to report experiencing it. The alternative to swallowing would be throat-clearing. To do this, the mouth should be closed and air should be
inhaled Inhalation (or Inspiration) happens when air or other gases enter the lungs. Inhalation of air Inhalation of air, as part of the cycle of breathing, is a vital process for all human life. The process is autonomic (though there are exceptions ...
hard into the nose. Inhaling forcefully through the nose will pull excess phlegm and nasal mucus down into the throat, where muscles in the throat and tongue can prepare to eject it. Once this is done, a U-shape should be formed with the tongue, while simultaneously forcing air and
saliva Saliva (commonly referred to as spit) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which DNA can be ...
forward with the muscles at the back of the throat. At this point, the phlegm will be in the mouth and is now ready to be spat out as
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked eye examination, microbiological investigation of respiratory infections and cytological investigations ...
.


Colors of phlegm

Phlegm can exist in different colors. The color could provide important clues about a person's health. * Yellow or green: Indicates an infection often by a virus or bacteria. The color is caused by an enzyme produced by the white blood cells combating the infection. * Clear: Indicates allergies. Mucus membranes produce
histamines Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered i ...
and make more phlegm. * Red: Indicates dry air. A nasal spray can be used to alleviate symptoms of a dry nose and throat. It can also occur due to blood (such as if the person had or has a
bleeding nose A nosebleed, also known as epistaxis, is bleeding from the nose. Blood can flow down into the stomach, and cause nausea and vomiting. In more severe cases, blood may come out of both nostrils. Rarely, bleeding may be so significant that lo ...
, or a lung malignancy).


Phlegm and humourism

Humourism Humorism, the humoral theory, or humoralism, was a system of medicine detailing a supposed makeup and workings of the human body, adopted by Ancient Greek and Roman physicians and philosophers. Humorism began to fall out of favor in the 1850s ...
is an ancient theory that the human body is filled with four basic substances, called the ''four humours'', which are held in balance when a person is healthy. It is closely related to the ancient theory of the four elements and states that all diseases and disabilities result from an excess or deficit in black bile, yellow bile, phlegm, and blood. Hippocrates, an ancient Greek medical doctor, is credited for this theory, about 400 BC. It influenced medical thinking for more than 2,000 years, until finally discredited in the 1800s. Phlegm was thought to be associated with
apathetic Apathy is a lack of feeling, emotion, interest, or concern about something. It is a state of indifference, or the suppression of emotions such as concern, excitement, motivation, or passion. An apathetic individual has an absence of interes ...
behaviour; this old belief is preserved in the word "
phlegmatic The four temperament theory is a proto-psychological theory which suggests that there are four fundamental personality types: sanguine, choleric, melancholic, and phlegmatic. Most formulations include the possibility of mixtures among the types w ...
". This adjective always refers to behaviour, and is pronounced differently, giving full weight to the "g": not /ˈflɛmatɪk/ but /flɛgˈmatɪk/. To have "phlegm" traditionally meant to have stamina and to be unswayed by emotion. Sir William Osler’s 188
Aequanimitas
discusses the imperturbability or calmness in a storm required of physicians. "'Imperturbability means coolness and presence of mind under all circumstances, calmness amid storm, clearness of judgment in moments of grave peril, immobility, impassiveness, or, to use an old and expressive word, phlegm."'' This was his farewell speech at the University of Pennsylvania in 1889 before becoming Physician-in-Chief at the recently founded Johns Hopkins Hospital in
Baltimore, Maryland Baltimore ( , locally: or ) is the most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic, and the 30th most populous city in the United States with a population of 585,708 in 2020. Baltimore was ...
. This is fro
''"Celebrating the Contributions of William Osler"''
in th
Alan Mason Chesney Medical Archives
of th
Johns Hopkins Medical Institutions
"'' The phlegm of Humourism is far from the same thing as phlegm as it is defined today. Nobel laureate Charles Richet MD, when describing humorism's "phlegm or pituitary secretion" in 1910 asked rhetorically, "this strange liquid, which is the cause of tumours, of chlorosis, of rheumatism, and cacochymia - where is it? Who will ever see it? Who has ever seen it? What can we say of this fanciful classification of humours into four groups, of which two are absolutely imaginary?"Charles Richet, MD, Professor of Physiology, University of Paris. Ancient Humorism and Modern Humorism. Delivered at the International Congress of Physiology held in Vienna, September 27th to 30th 1910, as reported on page 921 of the British Medical Journal of October 1, 1910:


Illnesses related to phlegm

Phlegm may be a carrier of larvae of intestinal parasites (see
hookworm Hookworms are intestinal, blood-feeding, parasitic roundworms that cause types of infection known as helminthiases. Hookworm infection is found in many parts of the world, and is common in areas with poor access to adequate water, sanitation, an ...
).
Bloody sputum Hemoptysis is the coughing up of blood or blood-stained mucus from the bronchi, larynx, trachea, or lungs. In other words, it is the airway bleeding. This can occur with lung cancer, infections such as tuberculosis, bronchitis, or pneumonia, and ...
can be a symptom of serious disease (such as tuberculosis), but can also be a relatively benign symptom of a minor disease (such as bronchitis). In the latter case, the sputum is normally lightly streaked with blood. Coughing up any significant quantity of blood is always a serious medical condition, and any person who experiences this should seek medical attention.
Apophlegmatism Apophlegmatisms, in pre-modern medicine, were medications chewed in order to draw away phlegm and humours from the head and brain. Such treatments were called ''apophlegmatic''. Of this kind, tobacco was considered excellent, except for the damag ...
s, in pre-modern medicine, were medications chewed in order to draw away phlegm and humours.


References

{{Authority control Body fluids Symptoms and signs: Respiratory system