The fixed-dose procedure (FDP), proposed in 1992 by the
British Toxicology Society, is a method to assess a substance's acute oral
toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a subs ...
.
In comparison to the older test developed in 1927, this procedure produces similar results while using fewer animals and causing less pain and suffering. As a result, in 1992 this test was proposed as an alternative to the LD50 test by the
Organisation for Economic Co-operation and Development under OECD Test Guideline 420. However, the U.S. Food and Drug Administration has begun to approve non-animal alternatives in response to research cruelty concerns and the lack of validity/sensitivity of animal tests as they relate to humans.
See also
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Up-and-down procedure
References
Further reading
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{{Toxicology
Toxicology tests