USP may refer to:

Government institutions

* ''Unité Spéciale de la Police'', Luxembourg * United States Penitentiary, a prison * Utah State Prison, Draper, US

Math and science

* Ultra-short period planets, orbiting planets with periods shorter than one day. * Ultraspiracle protein, a part of the ecdysone receptor * Universal stress protein, a protein superfamily * USp (2''n''), a symplectic group in the mathematics of group theory * USP grade, a level of chemical purity

Technology

* United States patent * Heckler & Koch USP pistol * Ultrashort pulse laser, a laser that emits ultrashort pulses of light, generally of the order of femtoseconds to hundreds of femtoseconds * Universal Storage Platform, brand name for a Hitachi Data Systems line of enterprise storage arrays * Unified shader model, Unified shader processors, used in GPUs * USP (Victoria), a Russian satellite bus

Universities

* University of São Paulo, a public university in Brazil * University of the Sciences in Philadelphia, United States * University of the South Pacific, a public university with a number of locations in Oceania * University of Southeastern Philippines, an educational institution in Mindanao, Philippines * University of Southern Philippines Foundation, an educational institution in Cebu, Philippines * University Scholars Program, a scholarly community at Duke University; see John Hope Franklin Center for Interdisciplinary and International Studies

Other uses

* Unified settlement planning * Unique selling proposition, in marketing * ''United States Pharmacopeia'' * Urs Samyuktha Paksha, an Indian political party * Useful space principle, in the game of bridge * Uttama Seva Padakkama, a military decoration in Sri Lanka * Uspantek language (ISO 639 code: usp), a Mayan language {{Disambiguation