Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of
Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (
PI3Ks).
Members
The human PIKK family includes six members:
Structure
PIKKs proteins contain the following four
domains:
#
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
FRAP-ATM- TRRAP (FAT) domain,
# kinase domain (KD;
PI3_PI4_kinase),
# PIKK- regulatory domain (PRD), and
#
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH). When the protein is ...
FAT-C-terminal (FATC) domain
References
External links
Kinase Family PIKKa
WikiKinome
EC 2.7.11
Protein families
{{protein-stub
