PDB may refer to:
* Chess Problem Database Server (PDB Server)
* 1,4-Dichlorobenzene (paradichlorobenzene)
* Party of German-speaking Belgians, (German: '), a political party and predecessor of the ProDG
* PDB (Palm OS), a container format for record databases in Palm OS, Garnet OS and Access Linux Platform
* ''Pee Dee Belemnite'', a standard for stable Carbon-13 and Oxygen-18 isotopes; see
* Pluggable database, such as an Oracle Database in a multitenancy environment
* Potato dextrose broth, a common microbiological growth media
* Pousette-Dart Band
* President's Daily Brief or Briefing or Bulletin, a top-secret intelligence document produced each morning for the President of the United States, U.S. President
* Program database, a file format for storing debugging information
* Promised Day Brigade, an Iraqi Shia Islam, Shia organisation
* Protein Data Bank
* Protein Data Bank (file format)
* Python Debugger, see Python (programming language)
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