NSC may refer to:

Sport and competition

* NSC United, an American soccer team * National Scholastics Championship, an American quiz bowl competition * National Scrabble Championship, now known as the Scrabble Players Championship * National Shooting Centre, historic British shooting sports complex near Bisley, United Kingdom * National Sports Center, an American sports complex * National Sports Centre (Isle of Man) * National Sports Club of India *Nejmeh SC, a Lebanese association football club * Nepean Sailing Club * North Star Conference, a women's college sports conference

Education

* National Senior Certificate, a South African educational certificate * Nehru Science Centre, Mumbai, India * Nevada State College * Northern Southland College, a secondary School in Lumsden, New Zealand * Yoshimoto New Star Creation, a Japanese comedy school

Transport

* National Security Cutter, a U.S. Coast Guard ship design * Network SouthCentral, a British railway company * Norfolk Southern Railway, an American railway company * North–South Corridor, Singapore, an expressway in Singapore * North Spokane Corridor, a freeway in Spokane, Washington, US

Medicine

* National Service Center of the US National Cancer Institute * National Skin Centre, a Singapore medical facility * Neural stem cell * Nursing Service Cross, an Australian Honours System medal

Banking and investment

* National Sort Code, an Irish bank code * Nomura Securities Co, an investment bank * National Savings Certificates (India), an Indian Government Savings Bond

Computing

* National Software Centre, an Irish organization * National Supercomputer Centre in Sweden * NetShow Channel, a streaming media system ** .nsc, the filename extension for NetShow Channel, now called Windows Media Station * Network Systems Corporation, a computer product manufacturer * NonStop Clusters, an SCO UnixWare add-on package

Other uses

* National Safety Council, an American nonprofit organization * National Salvation Committee, a Ukrainian organization * Ministry of Science and Technology (Taiwan), National Science Council, a government body in Taiwan renamed as Ministry of Science and Technology * National Security Committee (Australia), peak decision-making body for national security in the Australian Government * National Security Committee (Ireland), Irish interdepartmental committee on national security * National security council, a government body found in many countries * National Space Centre, a British tourist attraction * National Space Council, a panel of government and military officials dedicated to the review and improvement of the United States' space programs. * National Statistical Commission, an Indian organization * National Supervisory Commission, a Chinese anti-corruption agency * Necessary and sufficient condition, a concept in logic * New Safe Confinement, the structure intended to contain the nuclear reactor at Chernobyl, Ukraine * North-South Carrier, a Botswana water pipeline * Norwegian Space Centre * Newman & Spurr Consultancy, a UK company providing simulation and analysis-driven training {{disambiguation