Manetti is an Italian surname. Notable people with the surname include:
*Antonio Manetti (1423–1497), Italian mathematician and architect
*Domenico Manetti (1609–1663), Italian painter
*Giannozzo Manetti (1396–1459), Italian politician and diplomat
*Larry Manetti (born 1947), American actor
*Ricardo Mannetti (born 1975), Namibian footballer
*Rutilio di Lorenzo Manetti, (c. 1571 – 1639), Italian painter
*Saverio Manetti (1723–1785), Italian physician, botanist and ornithologist
*Teresa Maria Manetti, (1846–1910), Italian Roman Catholic nun
{{surnames
Italian-language surnames
