People
* David Letterman (born 1947), American television talk show host ** ''Late Night with David Letterman'', talk show that aired on NBC from 1982 to 1993 ** ''Late Show with David Letterman'', talk show that aired on CBS from 1993 to 2015 ** ''My Next Guest Needs No Introduction with David Letterman'', talk show carried by Netflix from 2018 to present ** Live on Letterman ** The Letterman Foundation for Courtesy and Grooming, a private foundation owned by David Letterman ** Rahal Letterman Lanigan Racing, an auto racing team * Jonathan Letterman (1824–1872), American surgeon known as the "Father of Battlefield Medicine" and brother of William Henry * William Henry Letterman (1832–1881), co-founder of the Phi Kappa Psi fraternity and brother of Jonathan * Russell Letterman (1933–1990) * Rob Letterman (1970)Places
* Letterman Digital Arts Center, the home of several Lucasfilm units, located on the site of the former Letterman Army Hospital * Letterman Army Hospital, hospital operating from 1898 to 1995 on the Presidio of San Francisco, named after Jonathan Letterman * Camp LettermanArt & culture
* The Lettermen, musical group * "Letterman", a 2017 song by American rapper Wiz Khalifa * The protagonist superhero from ''The Adventures of Letterman'', an animated segment on the children's show ''The Electric Company''See also
* Mail carrier {{disambiguation, surname.jpg.html){kind=link}