Interstate 580 is or was the designation for several Interstate Highways in the United States, all of which are related to Interstate 80:
*Interstate 580 (California), a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5
*Interstate 580 (Nevada), a spur connecting Carson City, Nevada to Reno, Nevada (also signed as U.S. Route 395)
*Interstate 580 (Nebraska), a former route and now part of U.S. Route 75 in Omaha, Nebraska
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Interstate 80, 5
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