Interstate 210 may refer to:
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Interstate 210 (California)
The Foothill Freeway is a freeway in the Los Angeles metropolitan area, California, running from the Sylmar district of Los Angeles east to Redlands. The western segment is signed as Interstate 210 (I-210) from its western end at I-5 to ...
or the Foothill Freeway, a major east–west freeway running through the valleys north and east of Los Angeles
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Interstate 210 (Louisiana), a bypass route in Lake Charles
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Interstate 310 (Mississippi), a proposed freeway in Biloxi, originally proposed as Interstate 210
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Interstate 165 in Mobile, Alabama, previously designated as Interstate 210
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