Histidyl-tRNA synthetase (HARS) also known as
histidine-tRNA ligase, is an
enzyme which in humans is encoded by the ''HARS''
gene.
Function
Aminoacyl-tRNA synthetases are a class of enzymes that charge
tRNAs with their cognate
amino acids. The protein encoded by this gene is a
cytoplasmic enzyme which belongs to the class II family of
aminoacyl tRNA synthetases
An aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto its corresponding tRNA. It does so by catalyzing the transesterification of a specific cognate amino acid or its pre ...
. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of
histidine into proteins.
The gene is located in a head-to-head orientation with
HARSL on chromosome five, where the homologous genes share a bidirectional
promoter.
Clinical significance
The gene product is a frequent target of
autoantibodies
An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases (notably lupus erythematosus) are associated with such antibodies.
Pr ...
in the human autoimmune disease
polymyositis/
dermatomyositis.
Interactions
HARS has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
EEF1B2 and
EEF1G.
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References
Further reading
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