H19 or H-19 may refer to:
*
H19 (gene), a maternally-transmitted human gene
* British NVC community H19, a type of Heaths in the British National Vegetation Classification system, heath community in the British National Vegetation Classification
* Heathkit H19, a serial terminal used with the Heathkit H8 microcomputer
* Highway H19 (Ukraine)
* , an H-class submarine ordered by but not commissioned into the Royal Navy
* , a Royal Navy H-class destroyer
* London Buses route H19, a public transportation route in London, England
* Sikorsky H-19, an American helicopter
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