GWB may refer to:
* Baylor University Golden Wave Band
* DeKalb County Airport (Indiana)
* The Geochemist's Workbench, a scientific modelling suite
* George Warren Brown School of Social Work of Washington University in St. Louis
* George Washington Bridge, linking Washington Heights, Manhattan to Fort Lee, New Jersey, United States
* George W. Bush (born 1946), 43rd president of the United States
* Gravitational wave background
* Great Western Bank (1907–present), an American bank
* gwb ISO code for the Gwa language
* Gypsum wall board, a.k.a. drywall, a construction material
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