Carbonic anhydrase II (gene name CA2), is one of sixteen forms of human
α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of
carbon dioxide. Defects in this enzyme are associated with
osteopetrosis and
renal tubular acidosis
Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body due to a failure of the kidneys to appropriately acidify the urine. In renal physiology, when blood is filtered by the kidney, the filtrate pas ...
.
Renal carbonic anhydrase allows the reabsorption of
bicarbonate ions in the proximal tubule.
Loss of carbonic anhydrase activity in bones impairs the ability of
osteoclasts to promote bone resorption, leading to osteopetrosis.
Interactions
Carbonic anhydrase II has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
band 3 and
sodium-hydrogen antiporter 1.
References
Further reading
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