CPN may refer to:
* Calpine Corporation, New York Stock Exchange symbol CPN
* Canadian Perinatal Network
* ''Carnivorous Plant Newsletter''
* Carpinteria (Amtrak station), California, Amtrak station code CPN
* Caspian Airlines (Iran), ICAO airline designator ''CPN''
* Celiac plexus neurolysis, in medicine, the chemical ablation of the celiac plexus
* Central Park North (disambiguation)
* Central Pattana, Stock Exchange of Thailand symbol ''CPN''
* ''Chlamydia pneumoniae'', generally Cpn or CpN
* Citizen Potawatomi Nation, a federally recognized tribe of Potawatomi people located in Oklahoma
* Clapham North tube station, London, London Underground station code CPN
* Coloured Petri net
* Communist Party of Nepal
* Communist Party of the Netherlands
* Community psychiatric nurse
* Complex projective space,
* Confederation of the Polish Nobility
* Country and Progressive National Party, early 20th-century political party in Queensland, Australia
* Lysine carboxypeptidase, an enzyme
* Community Protection Notice in the United Kingdom
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