C16 may refer to:
* , a 1908 British C-class submarine
* Sauber C16, a 1997 racing car
* IEC 60320 C16, an electrical connector used for electric kettles and other small appliances
* C16, the ICD-10 code for stomach cancer
* Caldwell 16 (NGC 7243), an open cluster in the constellation Lacerta
* C16 (drug), a protein kinase inhibitor used in scientific research
* C16 Close Area Suppression Weapon, the Heckler & Koch GMG's Canadian designation
* The 16th century A.D.
* Commodore 16, a home computer
* Palmitic acid, a common saturated fatty acid
C-16 may refer to:
* C-16 highway (Spain), a highway in Catalonia
* ''C-16: FBI'', a 1997–98 American TV series
* Bill C-16, a Canadian law regarding gender expression and gender identity
* The Cessna 208 airliner, as designated in the U.S. Army
*The French Defence, as coded in the Encyclopaedia of Chess Openings
* Carbon-16 (C-16 or 16C), an isotope of carbon
{{Letter-NumberCombDisambig
.jpg.html){kind=link}