AE2 may refer to:
* , E-class submarine of the Royal Australian Navy
*
Aero Ae 02, a design of Czechoslovakian plane
*
Anion Exchanger 2, transport protein
*
Ape Escape 2
* A size designation for
Constantinian bronze coins
* Applied Energistics 2, a popular mod for the video game ''
Minecraft
''Minecraft'' is a sandbox game developed by Mojang Studios. The game was created by Markus "Notch" Persson in the Java (programming language), Java programming language. Following several early private testing versions, it was first made pub ...
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*
Aminoestradiol, a synthetic estrogen
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