53 may refer to:
* 53 (number)
* one of the years 53 BC, AD 53, 1953, 2053
* FiftyThree, an American privately held technology company that specializes in tools for mobile creation and visual thinking
* 53rd Regiment Alabama Cavalry
* 53rd Regiment of Foot (disambiguation)
* 53rd Division (disambiguation)
* 53 (album), ''53'' (Jacky Terrasson album), 2019
* "Fifty Three", a song by Karma to Burn from the album ''Arch Stanton'', 2014
* Fifth Third Bank
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