Fezolamine (Win-41,528-2) is a
drug which was investigated by
Sterling Drug
Sterling Drug was an American global pharmaceutical company, also known as Sterling Winthrop, Inc. in its last years (after the merger with Winthrop-Stearns Inc. which itself resulted from the merger of ''Winthrop Chemical Company Inc.'' and '' ...
as an
antidepressant in the 1980s. The
isomeric ''N'',''N''-dimethyl-4,5-diphenyl-1''H''-pyrazole-1-propanamine was completely inactive in the primary antidepressant screens.
It acts as a
serotonin,
norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad' ...
, and
dopamine reuptake inhibitor
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmi ...
, with 3- to 4-fold preference for the former
neurotransmitter. It was found to be effective and well tolerated in
clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, diet ...
s but was never marketed.
See also
*
3,3-Diphenylcyclobutanamine
3,3,-Diphenylcyclobutanamine is a psychostimulant drug which was originally prepared as an antidepressant in the late 1970s. It appears to inhibit the reuptake of serotonin, norepinephrine, and dopamine, and may also induce their release as we ...
References
{{Monoamine reuptake inhibitors
Dimethylamino compounds
Serotonin–norepinephrine reuptake inhibitors
Pyrazoles