RefSeq (protein)



Location (UCSC) Chr 8: 144.47 – 144.48 Mb Chr 15: 76.67 – 76.67 Mb PubMed search [3] [4] Wikidata
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Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[5][6]


FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[6]


FOXH1 has been shown to interact with DRAP1[7] and Mothers against decapentaplegic homolog 2.[8][9][10][11][12]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160973 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033837 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell. 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198. 
  6. ^ a b "Entrez Gene: FOXH1 forkhead box H1". 
  7. ^ Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260. 
  8. ^ Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400. 
  9. ^ Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900Freely accessible. PMID 9858566. 
  10. ^ Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747Freely accessible. PMID 9389648. 
  11. ^ Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095Freely accessible. PMID 10938097. 
  12. ^ Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.