FOXH1
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Forkhead box protein H1 is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''FOXH1''
gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.


Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. ''FoxH1''is a transcription factor that contains a conserved function in chordates. ''FoxH1'', acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, ''FoxH''1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking ''FoxH1'' will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.


Interactions

FOXH1 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
DRAP1 Dr1-associated corepressor is a protein that in humans is encoded by the ''DRAP1'' gene. Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of ...
and
Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the ''SMAD2'' gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the ''Dros ...
.


See also

*
FOX proteins FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic ...


References

# ·     Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. ''PLoS Genet''. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072 # Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. ''Genes Dev''. 2001;15(10):1257-1271. doi:10.1101/gad.881501 # ·     von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. ''Dev Cell''. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023


Further reading

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External links

* Forkhead transcription factors {{gene-8-stub