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NM_021784
NM_153675

NM_001291065
NM_001291067
NM_010446

RefSeq (protein)

NP_068556
NP_710141

NP_001277994
NP_001277996
NP_034576

Location (UCSC) Chr 20: 22.58 – 22.59 Mb Chr 2: 148.04 – 148.05 Mb PubMed search [3] [4] Wikidata
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Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene.[5][6][7]

Function

Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125798 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037025 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: forkhead box A2". 
  6. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385. 
  7. ^ Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB (May 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. 277 (20): 17564–70. doi:10.1074/jbc.M111037200. PMID 11875061. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.