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NM_001300844
NM_001300855
NM_001300856
NM_001300857
NM_005438

NM_010235

RefSeq (protein)

NP_001287773
NP_001287784
NP_001287785
NP_001287786
NP_005429

NP_034365

Location (UCSC) Chr 11: 65.89 – 65.9 Mb Chr 19: 5.45 – 5.46 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[5][6]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[6]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)[7] and C-jun.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175592 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024912 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490. 
  6. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1". 
  7. ^ a b Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.