Four and a half LIM domains protein 3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''FHL3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
LIM proteins are defined by the possession of a highly conserved double
zinc finger
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized struct ...
motif called the
LIM domain
LIM domains are protein structural domains, composed of two contiguous zinc fingers, separated by a two-amino acid residue hydrophobic linker. The domain name is an acronym of the three genes in which it was first identified (LIN-11, Isl-1 and M ...
.
upplied by OMIMref name="entrez"/>
Function
FHL3 plays a role in myogenesis and also stimulates the development of neural crest by enhancing BMP signaling.
[Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signaling
Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq
bioRxiv 711192; doi: https://doi.org/10.1101/711192]
Interactions
FHL3 has been shown to
interact
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with:
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CREB1
CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the ''CREB1'' gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. T ...
,
[
* ]CTBP2
C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the ''CTBP2'' gene.
Function
The CtBPs - CTBP1, CtBP1 and CtBP2 in mammals - are among the best characterized transcriptional corepressors. They typicall ...
,FHL2
Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the ''FHL2'' gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.
Function
FHL-2 is thought to have a ...
,ITGA7
Alpha-7 integrin is a protein that in humans is encoded by the ''ITGA7'' gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, an ...
KLF3
Krüppel-like factor 3 is a protein that in humans is encoded by the ''KLF3'' gene.
Structure
KLF3, originally termed Basic Krüppel-like Factor (BKLF), was the third member of the Krüppel-like factor family of zinc finger transcription fact ...
.[
]
References
Further reading
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External links
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Transcription factors
{{gene-1-stub