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Express Scripts Holding Company is a pharmacy benefit management (PBM) organization. In 2017 it was the 22nd-largest company in the United States by total revenue as well as the largest pharmacy benefit management (PBM) organization in the United States. Express Scripts had 2016 revenues of $100.752 billion. Since December 20, 2018, the company has been a direct subsidiary of Bloomfield,
Connecticut Connecticut () is the southernmost state in the New England region of the Northeastern United States. It is bordered by Rhode Island to the east, Massachusetts to the north, New York (state), New York to the west, and Long Island Sound to the ...
-based
Cigna Cigna is an American multinational managed healthcare and insurance company based in Bloomfield, Connecticut. Its insurance subsidiaries are major providers of medical, dental, disability, life and accident insurance and related products and se ...
. The term "Scripts" in the company title refers to the widely used clipped version of prescription. Headquartered in Greater St. Louis within unincorporated North St. Louis County,
Missouri Missouri is a state in the Midwestern region of the United States. Ranking 21st in land area, it is bordered by eight states (tied for the most with Tennessee): Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas t ...
, Express Scripts provides integrated pharmacy benefit management services including network-pharmacy claims processing; home delivery pharmacy services; specialty pharmacy benefit management, through its subsidiary
Accredo Accredo is a specialty pharmaceutical and service provider for patients with complex and chronic health conditions. Accredo provides specialty drugs, drugs that cost more than $600 per month, with the average being $10,000 a month, which treat ser ...
; benefit-design consultation; drug-utilization review; formulary management; and medical and drug data analysis services to manage drug plans for health plans, self-insured employers and government agencies (both as administrator of employee benefits and public assistance programs). One of its largest clients is the
United States Department of Defense The United States Department of Defense (DoD, USDOD or DOD) is an executive branch department of the federal government charged with coordinating and supervising all agencies and functions of the government directly related to national sec ...
's Tricare program. Express Scripts also offers pharmacy benefit management services for workers' compensation insurance programs. The program is accredited by URAC, the nation's largest accrediting body for pharmacy benefit management companies. The company processes pharmaceutical claims for members through a network of retail pharmacies. Its own automated pharmacies dispense medications for chronic long-term diseases, such as diabetes or heart disease, directly to members by home delivery. On March 7, 2018, it was announced that
Cigna Cigna is an American multinational managed healthcare and insurance company based in Bloomfield, Connecticut. Its insurance subsidiaries are major providers of medical, dental, disability, life and accident insurance and related products and se ...
would buy Express Scripts in a $67 billion deal. The deal closed on December 20, 2018 at $54 billion, allowing Cigna to start offering new Express Scripts products to its corporate health insurance customers in 2019.


History


Founding

Express Scripts began in 1986 in St. Louis County, Missouri as a result of a joint venture between a retail chain of more than 79 pharmacies (Medicare Glaser Inc.) and Sanus Corp. Health Systems. Sanus traces its history to Bradford Systems and Administrative Services which was founded in
Boston Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- mo ...
in 1968. Bradford had a contract for computer processing of Medicare and Medicaid payments. It was acquired in 1981 by
McDonnell Douglas McDonnell Douglas was a major American aerospace manufacturing corporation and defense contractor, formed by the merger of McDonnell Aircraft and the Douglas Aircraft Company in 1967. Between then and its own merger with Boeing in 1997, it ...
through its McDonnell Automation Company (McAuto) subsidiary for $11.5 million. In 1983, two of McDonnell Douglas' former principals Joseph T. Lynaugh (a former director of
NYC Health + Hospitals NYC Health + Hospitals, officially the New York City Health and Hospitals Corporation (HHC), operates the public hospitals and clinics in New York City as a public benefit corporation. , HHC is the largest municipal healthcare system in the Un ...
in
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), the McAuto's project manager of the Bradford takeover, and Howard L. Waltman, a long time Bradford's employee, formed the Sanus Corporation with substantial investments and ownership from McDonnell Douglas including a McDonnell Douglas whole ownership of the St. Louis office.
General American Life Insurance Company MetLife, Inc. is the holding corporation for the Metropolitan Life Insurance Company (MLIC), better known as MetLife, and its affiliates. MetLife is among the largest global providers of insurance, annuities, and employee benefit programs, wi ...
invested in Sanus's future largest part based in New York. Sansa was a health maintenance organization and it merged with the General America Life Insurance
preferred provider organization In U.S. health insurance, a preferred provider organization (PPO), sometimes referred to as a participating provider organization or preferred provider option, is a managed care organization of medical doctors, hospitals, and other health c ...
. Sanus rapidly grew and by 1986 it had 200,000 clients and $100 million in revenue operated in the St. Louis,
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,
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,
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, and Washington, D.C. markets. It created a subsidiary called GenCare to fill prescriptions. In late 1986, Sanus announced a deal with St. Louis based pharmacy Medicare-Glaser for fulfilling prescriptions that would be 50-50 split ownership between Sanus and Medicare-Glaser called Express Scripts (scripts being medical industry jargon for prescriptions). Initial plans called for Missouri and Illinois clients to get their prescriptions at the Medicare-Glaser brick and mortar pharmacies while those in other cities could get their prescriptions via mail order—an innovation at the time. The initial report of the creation said that Charles H. Ridings, formerly in charge of McDonnell Douglas mergers and acquisitions, was named the first chief executive, although he was quickly replaced by Waltman. Sanus remained the dominant early insurance customer but Express Scripts began marketing to other providers. With increased investment by New York Life, Sansus change its name to NYL Cares and in 1998 was sold to Aetna for $1.05 billion. Glaser Drug Company sold its Express Scripts partnership interest back to Sanus before it was acquired by chain SupeRx in 1989 for $18.2 million. SupeRX declared bankruptcy and all stores closed in 1991 after
Walgreens Walgreen Company, d/b/a Walgreens, is an American company that operates the second-largest pharmacy store chain in the United States behind CVS Health. It specializes in filling prescriptions, health and wellness products, health information, a ...
acquired the pharmacy records. SupeRX's loan to buy Glaser Drug Co. had been financed by Lincoln Savings and Loan Association. Morris Glaser had founded the company on October 1, 1924. In 1959, Glaser opened discount pharmacies, which would be called Medicare Pharmacy. The discount pharmacies were designed to resemble a doctor waiting room and were only about 800 to 1,000 square feet which focused just on the prescriptions. The two companies although sharing the same name operated separately, peaking at 100 stores. General America, which had been a private St. Louis-based insurance since 1933, was acquired by
MetLife MetLife, Inc. is the Holding company, holding corporation for the Metropolitan Life Insurance Company (MLIC), better known as MetLife, and its affiliates. MetLife is among the largest global providers of insurance, Annuity (US financial produc ...
for $1.2 billion in 1999. General America had run into financial problems and had said it could not pay back $6.8 billion in short term bonds to investors.


1989-1999

Express Scripts was purchased by New York Life Insurance Company in 1989 and became a publicly traded company in 1992. In 1993, Express Scripts signed on both FHP International and Maxicare Health Care and corporate clients Lockheed, Service Merchandise, and
Ingersoll-Rand Ingersoll Rand is an American multinational company that provides flow creation and industrial products. The company was formed in February 2020 through the spinoff of the industrial segment of Ingersoll-Randplc (now known as Trane Technologies) ...
. In 1994, the company expanded its services by adding
workers’ compensation Workers' compensation or workers' comp is a form of insurance providing wage replacement and medical benefits to employees injured in the course of employment in exchange for mandatory relinquishment of the employee's right to sue his or her emp ...
prescription services and
reinsurance Reinsurance is insurance that an insurance company purchases from another insurance company to insulate itself (at least in part) from the risk of a major claims event. With reinsurance, the company passes on ("cedes") some part of its own ins ...
. In 1994, the company announced a two-for-one stock split, and in 1996 established Express Scripts Canada. The same year, the company began the annual Drug Trend Report and launched the Outcomes Symposium Conference. In April 1998, Express Scripts acquired ValueRx, the PBM business of Columbia/HCA Healthcare Corp. The following year, in April 1999, the company purchased
Diversified Pharmaceutical Services Diversified Pharmaceutical Services entered the market in 1976 as the pharmacy benefit manager for United HealthCare, a leading managed care organization. It pioneered many cost containment strategies that are now core pharmacy benefit manager ...
from SmithKline Beecham Corp for $700 million. That same year, the company purchased stock in PlanetRx.com. This partnership offered members options for purchasing prescriptions and over-the-counter health products online.


2000-2010

In 2000, the company had to write off its $165 million relationship with PlanetRx.com when the startup experienced financial difficulties. In 2001, Express Scripts partnered with Merck-Medco and Advance PSC to form RxHub LLC. In 2002, Express Scripts, Inc. (ESI) acquired National Prescription Administrators, Inc. (NPA). In late December 2006, Express Scripts made a proposal to purchase Caremark. Express Scripts lost the race to acquire Caremark to CVS Corporation, which became CVS/Caremark Corporation on March 22, 2007. In October 2007, Express Scripts acquired ConnectYourCare, and now handles FSA, HRA and HSA accounts for companies such as Suntrust, Zions Bancorporation and Allegis. However, Express Scripts divested ConnectYourCare in August 2012. On April 13, 2009, it was announced that
Indianapolis Indianapolis (), colloquially known as Indy, is the state capital and most populous city of the U.S. state of Indiana and the seat of Marion County. According to the U.S. Census Bureau, the consolidated population of Indianapolis and Marion ...
-based WellPoint (now Anthem) had agreed to sell its NextRx subsidiaries for $4.675 billion to Express Scripts. Express Scripts closed the transaction in December 2009.


2010-present

In April 2012, Express Scripts completed a $29.1 billion acquisition of Medco Health Solutions. The
Federal Trade Commission The Federal Trade Commission (FTC) is an independent agency of the United States government whose principal mission is the enforcement of civil (non-criminal) antitrust law and the promotion of consumer protection. The FTC shares jurisdiction o ...
gave formal approval on April 2, 2012 after an anti-trust investigation. The acquisition positioned Express Scripts Holding Co. as the largest pharmacy benefit manager, filling 1.4 billion annual prescriptions. In 2017, Express Scripts launched Inside Rx, a partially owned subsidiary that provides discounts on medications for the uninsured and underinsured. In July 2017, Express Scripts purchased myMatrixx, a workers' compensation pharmacy benefits company based in Tampa, for $250 million. In October 2017, Express Scripts lost its biggest client, Anthem, which said it would not renew the PBM contract in 2019 and would instead use
CVS Health CVS Health Corporation (previously CVS Corporation and CVS Caremark Corporation) is an American healthcare company that owns CVS Pharmacy, a retail pharmacy chain; CVS Caremark, a pharmacy benefits manager; and Aetna, a health insurance pro ...
. Anthem alleged in court filings that Express had overcharged it by $3 billion. Anthem said that it would launch its own competing PBM service, IngenioRx. The battle between the two companies in 2017 caused Express Scripts stock to drop by nearly a third. Express Scripts announced its acquisition of eviCore in October 2017. The $3.6 billion deal closed that December. In November 2017, Express Scripts announced it was divesting United BioSource Corp. (UBC), its pharmaceutical support business. UBC was sold to Avista Capital Partners. In March 2018,
Cigna Cigna is an American multinational managed healthcare and insurance company based in Bloomfield, Connecticut. Its insurance subsidiaries are major providers of medical, dental, disability, life and accident insurance and related products and se ...
, which earlier was blocked by courts from being acquired by Anthem, announced a $67 billion deal to acquire Express Scripts. The Express Scripts acquisition would be the last major deal involving the country's largest PBMs. In 2017, CVS Health announced a merger with Aetna, completing in November 2018. The takeover of PBMs have drawn regulator resistance because of fears they foster an anti-competitive environment. Insurance companies have charged that the PBM model has contributed to high drug prices because PBMs take a commission on each transaction. Express Scripts has 30,000 employees worldwide. The company volunteers with local
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organizations. In December 2018, it was reported that
Walmart Walmart Inc. (; formerly Wal-Mart Stores, Inc.) is an American multinational retail corporation that operates a chain of hypermarkets (also called supercenters), discount department stores, and grocery stores from the United States, headquarter ...
and Express Scripts extended their network agreement to give Express Scripts' clients access to Walmart's prescription services. In December 2019, Express Scripts entered into a three-year partnership with Prime Therapeutics. In late 2020, Express Scripts and several subsidiaries were rebranded and reorganized into a distinct health services organization, Evernorth. Evernorth CEO
Tim Wentworth Timothy C. Wentworth (born 1959/60) is an American businessman. He is the former CEO of Evernorth, Cigna's health services platform and the former CEO of Express Scripts, the United States' largest pharmacy benefit manager. Education Wentworth gr ...
retired at the end of 2021 and Cigna veteran executive Eric Palmer became Evernorth CEO starting in 2022.


Finances

For the fiscal year 2017, Express Scripts reported earnings of US$4.517 billion, with an annual revenue of US$100.065 billion, a decline of 0.2% over the previous fiscal cycle. Express Scripts shares traded at over $64 per share, and its market capitalization was valued at over US$53.6 billion in October 2018.


World headquarters

Express Scripts is headquartered within Greater St. Louis in North St. Louis County,
Missouri Missouri is a state in the Midwestern region of the United States. Ranking 21st in land area, it is bordered by eight states (tied for the most with Tennessee): Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas t ...
. In 2007, the company became the first and only
Fortune 500 The ''Fortune'' 500 is an annual list compiled and published by ''Fortune (magazine), Fortune'' magazine that ranks 500 of the largest United States Joint-stock company#Closely held corporations and publicly traded corporations, corporations by ...
company to open a headquarters on a college campus when it opened its headquarters at 1 Express Way on the north edge of the
University of Missouri–St. Louis The University of Missouri–St. Louis (UMSL) is a public research university in St. Louis, Missouri. Established in 1963, it is one of four universities in the University of Missouri System and its newest. Located on the former grounds of Belle ...
north of University Place Drive and south of Interstate 70. A second headquarters building adjoining the original one opened in 2008. Three additional structures have been added to the NorthPark development on the north side of I-70 including an Office and Data Center, Tech and Innovation Center, and Operations Center. The area north of I-70 is separate from the university. In 2018 the majority of the 5,000 St. Louis Express Scripts employees work in the complex.
George Paz George Paz (died October 23, 2022, age 67) was the chairman, and former CEO, of Express Scripts, a Fortune 100 company, and the largest pharmacy benefit management (PBM) organization in the US. Career Paz, the grandson of Mexican immigrants, stu ...
, CEO of Express Scripts at the time of the move, was an UMSL graduate. Express Scripts, which rather owns both its headquarters and nearby office buildings, received substantial tax breaks. Since the move the company has been an active partner with the university including contributing money to renovate the computer sciences building (Express Scripts Hall), raising funds for building projects, sponsoring a pre-collegiate bridge program for high school students and sponsoring a small business incubator. Express Scripts throughout its entire history has been in St. Louis County, Missouri rather than the
City of St. Louis St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the bi-state metropolitan area, which ...
. It was originally headquartered in Maryland Heights, Missouri, and its current headquarters is about 4 miles west of the St. Louis city limits and its two building headquarters campus is actually spread across three jurisdictions. The entrance to the main building is located in
Cool Valley, Missouri Cool Valley is a city in St. Louis County, Missouri, United States in Greater St. Louis. The population was 1,196 at the 2010 census. Geography According to the United States Census Bureau, the city has a total area of , all land. Demographics ...
. The southeast portion of the campus is in Bellerive, Missouri and the southwest corner of the two-building complex is in unincorporated St. Louis County. The three buildings north of I-70 are in Berkeley, Missouri.


Chief executives

* Howard L. Waltman (1986-1992) * Barrett A. Toan (1992-2005) *
George Paz George Paz (died October 23, 2022, age 67) was the chairman, and former CEO, of Express Scripts, a Fortune 100 company, and the largest pharmacy benefit management (PBM) organization in the US. Career Paz, the grandson of Mexican immigrants, stu ...
(2005-2016) *
Tim Wentworth Timothy C. Wentworth (born 1959/60) is an American businessman. He is the former CEO of Evernorth, Cigna's health services platform and the former CEO of Express Scripts, the United States' largest pharmacy benefit manager. Education Wentworth gr ...
(2016–2021)


Drug Trend Report

Published annually since 1993, the Express Scripts Drug Trend Report provides detailed analysis of prescription drug costs and utilization. Now a web-based version, the Drug Trend Report is developed and published by the Express Scripts Research & New Solutions Lab with contributors from researchers, clinicians and others. This type of research is designed to understand consumer behavior relative to healthcare benefits.


Health decision science

Health science The following outline is provided as an overview of and topical guide to health sciences: Health sciences are those sciences which focus on health, or health care, as core parts of their subject matter. Health sciences relate to multiple aca ...
is the study of how people make decisions, and how to help them make better ones. Upon the merger of Express Scripts and Medco Health Solutions, the company came up with its own approach to understand its members health concerns, which it has dubbed Health Decision Science. This involves looking at three scientific disciplines: behavioral science or “consumerology”, clinical specialization, and actionable data. Because of its position between pharmacies and health care plans, Express Scripts sees 1.4 billion prescriptions a year, and it uses this information as part of its research data to create better solutions for clients and patients.


Controversy


Fraud allegations

On August 4, 2004, New York State
Attorney General In most common law jurisdictions, the attorney general or attorney-general (sometimes abbreviated AG or Atty.-Gen) is the main legal advisor to the government. The plural is attorneys general. In some jurisdictions, attorneys general also have exec ...
Eliot Spitzer filed a lawsuit against Express Scripts alleging that the company had kept tens of millions of dollars in drug rebates owed to the state. The suit was filed in the
New York Supreme Court The Supreme Court of the State of New York is the trial-level court of general jurisdiction in the New York State Unified Court System. (Its Appellate Division is also the highest intermediate appellate court.) It is vested with unlimited civ ...
in Albany County. The lawsuit further claimed that Express Scripts had overstated the cost benefits of switching to certain preferred medications. In 2008 the company settled the lawsuit, agreeing to pay $9.3 million to
Pennsylvania Pennsylvania (; ( Pennsylvania Dutch: )), officially the Commonwealth of Pennsylvania, is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States. It borders Delaware to its southeast, ...
and 28 other states to resolve claims of deceptive business practices. As part of the settlement, the company also agreed to change its business practices and pay up to $200,000 in reimbursement to patients.


Information breach

In October 2008, the St. Louis headquarters received an anonymous letter that contained sensitive information about 75 members. The extortionist stated that they would release more of similar records if the company failed to pay an unspecified amount of money. A consumer class action lawsuit against Express Scripts was brought on by John Amburgy, a
Missouri Missouri is a state in the Midwestern region of the United States. Ranking 21st in land area, it is bordered by eight states (tied for the most with Tennessee): Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas t ...
man, who accused the company of negligence in protecting customer records. The case was dismissed when Amburgy failed to show how he was directly affected by the breach.


Rockford lawsuit

The city of Rockford, Illinois is now suing Mallinckrodt Pharmaceuticals and Express Scripts for their failure to reduce the prescription drug Acthar's price. The suit alleges that Express Scripts had a contract to be the exclusive distributor of Acthar, and therefore benefited from its higher price. The company said in an email to 60 Minutes that there was no conflict of interest.


Reimbursements

Express Scripts is known to reimburse pharmacies below cost for medications and push patients to only use their mail order service. They then will spread price the medication and charge the plan sponsor a much higher price for the medication than they will reimburse pharmacies for.


References


External links

*
Research site

CuraScript SD site

Drug Trend Report

Accredo site

UBC
{{Authority control 1986 establishments in Missouri American companies established in 1986 Companies based in St. Louis County, Missouri Companies formerly listed on the Nasdaq Health care companies established in 1986 1992 initial public offerings Pharmacy benefit management companies based in the United States Specialty drugs Health care companies based in Missouri 2018 mergers and acquisitions