Excision repair cross-complementing (ERCC) is a set of proteins which are involved in

DNA repair DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA dam ...

. In humans, ERCC proteins are transcribed from the following genes: ERCC1,

ERCC2 __NOTOC__ ERCC2, or XPD is a protein involved in transcription-coupled nucleotide excision repair. The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 exons and 21 introns. The XPD protein contains 760 amino acids and is a polypeptide w ...

ERCC3 XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex. Structure The 3D-structure of the archaeal homolog of XPB has been solved by X-ray crystallography by Dr. Jo ...

, ERCC4,

ERCC5 DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ''ERCC5'' gene. Function Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation gro ...

ERCC6 DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ''ERCC6'' gene. The ''ERCC6'' gene is located on the long arm of chromosome 10 at position 11.23.NIH. "ERCC6 Gene." Genetics Home Reference. Natio ...

, and

ERCC8 DNA excision repair protein ERCC-8 is a protein that in humans is encoded by the ''ERCC8'' gene. This gene encodes a WD repeat protein, which interacts with the Cockayne syndrome type B (CSB) and p44 proteins, the latter being a subunit of the R ...

. Members 1 though 5 are associated with

Xeroderma Pigmentosum Xeroderma pigmentosum (XP) is a genetic disorder in which there is a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light. Symptoms may include a severe sunburn after only a few minutes in the sun, freckling in sun- ...

. Members 6 and 8 are associated with

Cockayne syndrome Cockayne syndrome (CS), also called Neill-Dingwall syndrome, is a rare and fatal autosomal recessive neurodegenerative disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosen ...

References

DNA repair {{protein-stub