Evodiamine is a

chemical compound A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element ...

extracted from the plant genus ''

Tetradium ''Tetradium'' is a genus of trees in the family Rutaceae, occurring in temperate to tropical east Asia. In older books, the genus was often included in the related genus '' Euodia'' (sometimes written, "''Evodia''" from latin spelling), but that ...

'', which has been shown to reduce fat uptake in mouse studies. It is suspected that its

mechanism of action In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targ ...

is similar to that of

capsaicin Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) ( or ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a chemical irritant for mammals, including humans, and produces a sensation of burnin ...

. As such, it has been included in some dietary supplements. Neither its fat-burning effects in humans nor any potential side effects have been empirically established. Evodiamine acts primarily as a

thermogenic Thermogenic means tending to produce heat, and the term is commonly applied to drugs which increase heat through metabolic stimulation, or to microorganisms which create heat within organic waste. Approximately all enzymatic reaction in the huma ...

and

stimulant Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...

. Evodiamine may also act by increasing the number of

serotonin transporter The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein tha ...

s available in the brain, enhancing the reuptake of serotonin.

References

{{Transient receptor potential channel modulators Stimulants Lactams Nitrogen heterocycles Indole alkaloids