Epidermal nevus syndrome (also known as "Feuerstein and Mims syndrome",
and "Solomon's syndrome"
[Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .]) is a
rare disease
A rare disease is any disease that affects a small percentage of the population. In some parts of the world, an orphan disease is a rare disease whose rarity means there is a lack of a market large enough to gain support and resources for discov ...
that was first described in 1968 and consists of extensive epidermal
nevi
Nevus (plural nevi) is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. The term originates from ''nævus'', which is Latin for "birthmark"; however, a nevus can be either congenital (present at bir ...
with abnormalities of the
central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...
(CNS), skeleton, skin,
cardiovascular system,
genitourinary system and eyes.
[James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. .] However, since the syndrome's first description, a broader concept for the "epidermal nevus" syndrome has been proposed, with at least six types being described:
[Happle, R. "Epidermal nevus syndrome." ''Semin Dermatol''. 1995;14:111.]
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Schimmelpenning syndrome
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Nevus comedonicus syndrome
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Pigmented hairy epidermal nevus syndrome
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Proteus syndrome
Proteus syndrome is a rare disorder with a genetic background that can cause tissue overgrowth involving all three embryonic lineages. Patients with Proteus syndrome tend to have an increased risk of embryonic tumor development.Freedberg, et al. ...
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CHILD syndrome
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Phakomatosis pigmentokeratotica
Phakomatosis pigmentokeratotica is a rare neurocutanous condition characterized by the combination of an organoid sebaceous nevus and speckled lentiginous nevus.James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the S ...
See also
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Epidermis
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List of cutaneous conditions
References
External links
Epidermal nevi, neoplasms, and cysts
Rare syndromes
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